Cast of Doc (2025 TV Series): Full Cast List

If you picked up the remote during the past year and wondered whether Doc was that British comedy about a grumpy doctor in Cornwall — or maybe the Italian medical drama that’s been kicking around since 2020 — you weren’t alone. The Fox series that debuted in January 2025 shares the name but tells a completely different story: one built around Molly Parker’s Dr. Amy Larsen, who wakes up unable to remember the last eight years of her own life. It landed on your screen with a fresh premise, a new ensemble, and enough momentum to earn three seasons before its second episode count even wrapped. This is the cast driving that story forward.

Lead Actress: Molly Parker as Dr. Amy Larsen · Core Cast: Omar Metwally, Jon-Michael Ecker, Amirah Vann · Season 2 Addition: Felicity Huffman

The key facts table below consolidates the essential metadata for Doc (2025 TV series) as verified across multiple sources.

Who plays the Irish priest on Doc season 2?

Timothy V. Murphy appears in Season 2 as Chaplain Eamon O’Leary, bringing a spiritual dimension to the hospital setting. His character offers pastoral care and emotional support to both patients and staff navigating the high-stakes medical environment. Murphy is a familiar face in television drama, with credits across series including Yellowstone and NCIS: Los Angeles. In Doc, his chaplain role positions him at the intersection of faith and medicine — a dynamic that adds a different kind of depth to the hospital’s interpersonal landscape. The character of Chaplain O’Leary provides a quiet anchor amid the chaos of hospital life, a role that becomes particularly relevant as storylines delve into the personal stakes behind Amy’s memory loss journey.

Timothy V. Murphy as Chaplain Eamon O’Leary

Who is the new lady on Doc?

Felicity Huffman joined the cast in June 2025 as Dr. Joan Ridley, the incoming Chief of Internal Medicine — making her the new authority figure who stands between Dr. Amy Larsen and her former position. The Emmy-winning actress brings award-tested gravitas to the role of Amy’s mentor, a dynamic that introduces professional tension and mentorship complexity as the two doctors navigate power shifts in the hospital hierarchy. Huffman, best known for her work on Desperate Housewives and American Crime, came aboard as a new series regular on June 10, 2025. Dr. Ridley isn’t just a figurehead, though — her arrival reshapes the professional landscape for every character who’s been watching Amy’s career unravel and rebuild. The “new lady” question gets a layered answer: Huffman is both a respected addition to the cast and a direct challenge to Amy’s standing within the hospital walls.

“She can rely only on her estranged 17-year-old daughter, whom she remembers as a 9-year-old, and a handful of devoted friends, as she struggles to continue practicing medicine, despite having lost nearly a decade of knowledge and experience.”

— Rotten Tomatoes, official series description

Felicity Huffman in season 2

How many seasons are there of the Doc?

Doc has aired two seasons as of late 2025, with Season 2 premiering on September 14, 2025. Season 1 ran from January through early 2025 on Fox, and the series earned a second-season renewal in February 2025 — before Season 1 had even wrapped. The momentum didn’t stop there: Fox confirmed a third season in March 2026. That puts Doc at three seasons greenlit across its first fifteen months of existence. Season 2 features 22 episodes, giving the expanded cast — including Huffman and the promoted series regulars — room to develop beyond the original ensemble that launched in January 2025.

Season 1 cast

The inaugural season established the core ensemble: Molly Parker as the amnesiac Dr. Amy Larsen, Omar Metwally as her ex-husband and current Chief Medical Officer Dr. Michael Hamda, Jon-Michael Ecker as her boyfriend Dr. Jake Heller, and Amirah Vann as her best friend Dr. Gina Walker. Supporting regulars Anya Banerjee (Dr. Sonya Maitra) and Patrick Walker (Dr. TJ Coleman) rounded out the hospital family, with Charlotte Fountain-Jardim playing Katie Hamda, Amy and Michael’s daughter. Scott Wolf appeared in a recurring capacity as Dr. Richard Miller.

Season 2 updates

Season 2 brought new faces and promotions. Felicity Huffman entered as Dr. Joan Ridley. Timothy V. Murphy joined the ensemble as Chaplain O’Leary. Patrick Walker and Charlotte Fountain-Jardim, who had been recurring in Season 1, were both promoted to series regulars on May 28, 2025. Emma Pfitzer Price came aboard in a recurring capacity as of August 13, 2025. Blair Underwood appeared as a special guest in Season 2, with a full Season 3 role already confirmed.

Is there going to be a Doc season 2?

Not only is there a Season 2 — it already aired. Fox renewed the series in February 2025 and dropped the second season on September 14, 2025, complete with 22 episodes. By the time audiences were finishing Season 2, Fox had already announced a third season for March 2026. So the “is there going to be” question is quietly outdated: the show has leapfrogged straight past wondering about renewal to expanding its cast and committing to longer arcs. Season 2 brought Huffman into the mix, expanded the regular count, and set up Blair Underwood’s expanded role for the third installment.

“After a brain injury erases the last eight years of Dr. Amy Larsen’s life, she must navigate an unfamiliar world where she has no recollection of patients she’s treated, colleagues she’s crossed, the soulmate she divorced, the man she now loves or the tragedy that caused her to push everyone away.”

— Rotten Tomatoes, official series description

Season 2 trailer details

Trailers for Season 2 centered on Amy’s ongoing struggle with her fractured memory and introduced Dr. Ridley’s arrival as both a professional threat and potential ally. The promotional material emphasized the personal stakes driving the hospital drama — specifically, Amy’s relationships with the colleagues she can’t remember and the daughter who’s grown up without her. Huffman featured prominently in the marketing, signaling her role as a central figure in the season’s narrative.

Main Cast of Doc (2025 TV Series)

The ensemble at the center of Doc revolves around a single fractured protagonist and the people who surround her. Every major character is positioned relative to Dr. Amy Larsen — as a former spouse, a current love interest, a best friend, a subordinate, a superior, or a family member she barely remembers. The casting choices reinforce that interdependence rather than building individual star vehicles. Molly Parker’s lead performance anchors the show’s emotional premise, but the chemistry across the ensemble carries the interpersonal weight.

Molly Parker

Molly Parker landed the lead role on December 19, 2023, nearly a year before the show premiered. She plays Dr. Amy Larsen, an attending physician in internal medicine who loses eight years of memories following an accident — meaning she can’t remember the colleagues she’s worked with, the patients she’s treated, the man she divorced, or the man she now loves. Parker’s performance has been central to the show’s ability to make the amnesia premise feel grounded rather than melodramatic. She’s an established dramatic actress with credits spanning Deadwood, House of Cards, and The Tattooist of Auschwitz — her casting signaled from the start that Doc was aiming for more than generic network drama. The character of Dr. Larsen requires both physical composure in medical scenes and emotional rawness in the personal fallout of memory loss, and Parker delivers both.

Omar Metwally

Omar Metwally was announced as a series regular alongside three other actors on March 4, 2024. He plays Dr. Michael Hamda, Chief Medical Officer at the hospital and Amy’s ex-husband. The executive title and the ex-spouse status are both relevant: Michael holds institutional power while also carrying the personal history of a failed marriage. His character exists at the intersection of professional authority and intimate failure — someone who’s moved on emotionally while still being forced to work alongside the woman who forgot why they fell apart. Metwally’s role positions him as both Amy’s colleague and her most complicated relationship, a dual function that drives significant dramatic tension throughout both seasons.

Jon-Michael Ecker

Jon-Michael Ecker plays Dr. Jake Heller, the chief resident who becomes Amy’s boyfriend — in the timeline she doesn’t remember. That detail carries significant dramatic weight: Jake represents a romantic connection Amy’s fractured mind has no record of, making every interaction with him a mix of professional awkwardness and personal uncertainty. Ecker brings romantic lead energy to the role while grounding it in the day-to-day reality of hospital hierarchy. His character stands in contrast to Michael’s situation — where Amy’s ex-husband represents a past she can’t access, Jake represents a present she’s learning about from scratch.

Amirah Vann

Amirah Vann plays Dr. Gina Walker, a neuropsychiatrist and Amy’s best friend. Neuro-psychiatry is a telling detail in the casting: the character specializing in brain and behavior is positioned as the protagonist’s closest confidante, someone who has professional as well as personal motivation for understanding Amy’s condition. Vann is a recognizable television presence from her work on Queen Sugar, where she built a reputation for nuanced dramatic performance. In Doc, her role as Amy’s anchor in the hospital environment provides emotional stability amid the chaos of fractured memories and shifting relationships.

The main cast table below details each actor’s character and role within the hospital hierarchy.

Is Doc on Fox based on a true story?

The original inspiration is real. Doc – Nelle tue mani, the Italian series that Fox’s 2025 Doc adapts, was inspired by the true story of Dr. Pierdante Piccioni, former chief of the emergency room at Lodi and Codogno hospitals in Italy. Dr. Piccioni forgot the previous 12 years of his life following a 2013 car accident — the real-world event that became the structural backbone of both the Italian show and its American counterpart. The American version compresses the memory loss from 12 years to 8 years and relocates the story from Italy to an American hospital setting, but the core premise of a brilliant doctor relearning their own professional life comes directly from what happened to Piccioni. The Fox series is fiction, but it’s fiction built on a documented medical case with a name, a hospital, and a specific timeline.

What happened to her son on Doc?

The show’s official descriptions don’t center a son — they focus on Amy’s fractured relationship with her estranged daughter Katie, who she last remembers as a 9-year-old and now discovers as a 17-year-old. What the series establishes consistently is a personal tragedy driving Amy’s self-imposed isolation before the accident, the fallout that caused her to push everyone away. The memory loss then compounds that original fracture: not only did Amy distance herself from her family, she literally can’t remember why. Whether a child is involved in that tragedy isn’t explicitly detailed in public-facing promotional material, but the show’s core emotional engine is family rupture and reconstruction — specifically the parent-daughter dynamic that has to be rebuilt from the ground up.

Where to watch Doc (2025 TV series)?

Doc airs on Fox with new episodes broadcast weekly. The network streams full seasons through its digital platforms, and episodes are available the day after broadcast. As a Fox production, the show falls within the broader streaming ecosystem where network content typically becomes available — check Fox’s official streaming options for the most current episode availability and any seasonal windows that may affect access.

Who is in the cast of Doc (2025 TV series) episodes?

The core ensemble appears across every episode of both seasons — Parker, Metwally, Ecker, Vann, and Banerjee form the consistent spine. Supporting cast members including Patrick Walker, Charlotte Fountain-Jardim, and Scott Wolf appeared in recurring capacities in Season 1 before transitioning to regular status or departing, depending on the storyline. Guest stars cycle through on a per-episode basis for specific medical cases, specialist consultations, and character-specific developments. Season 2 introduced the highest-profile guest addition in Timothy V. Murphy as Chaplain O’Leary, with Felicity Huffman entering as a new series regular rather than a one-episode guest.

Is Doc (2025) renewed for more seasons?

Yes, and the renewal pace has been unusually aggressive. Fox confirmed Season 3 in March 2026, which means three seasons were greenlit within the show’s first eighteen months. That’s a strong signal of network confidence, particularly for a drama without an existing franchise name to lean on. The question has shifted from “will there be more” to “how will the show evolve” — particularly with Blair Underwood’s expanded role, Huffman’s continued presence as Dr. Ridley, and the question of what happens to Amy’s career once the mentorship arc with her new superior develops.

Who are the doctors in Doc (2025 TV series)?

The medical staff at the center of Doc runs across several specialties and hierarchical levels. Dr. Amy Larsen is an attending physician in internal medicine and former Chief of Internal Medicine — a position that makes her both clinically accomplished and institutionally wounded. Dr. Michael Hamda serves as Chief Medical Officer, holding the top administrative role in the hospital while also being Amy’s ex-husband. Dr. Jake Heller is the chief resident, one level below attending physician and Amy’s current romantic partner. Dr. Gina Walker is a neuropsychiatrist — a detail that matters because her specialty in brain and behavior directly relates to understanding Amy’s condition. Dr. Sonya Maitra and Dr. TJ Coleman are both residents at different stages of training, with Sonya as a third-year and TJ as a first-year. Dr. Richard Miller briefly occupied Amy’s former position as Chief during her recovery period. Dr. Joan Ridley, played by Felicity Huffman, arrives in Season 2 as the new Chief of Internal Medicine, bringing Amy’s old role into someone else’s hands.

Rotten Tomatoes captures the show’s emotional premise cleanly: “After a brain injury erases the last eight years of Dr. Amy Larsen’s life, she must navigate an unfamiliar world where she has no recollection of patients she’s treated, colleagues she’s crossed, the soulmate she divorced, the man she now loves or the tragedy that caused her to push everyone away.” That official description frames the show as a character study wrapped in medical drama packaging — and it’s an accurate one. The premise is unusual for network television precisely because it asks the audience to care about a protagonist who can’t remember her own history, which puts every relationship in perpetual negotiation. Parker’s performance carries that weight, and the ensemble around her gives her something to push against.

The addition of Felicity Huffman in Season 2 is the most significant cast development since the show launched. Her Emmy-winning credentials change the show’s casting profile in a way that’s meaningful for both critical perception and audience expectation. Huffman doesn’t coast on reputation — her character is architecturally important, serving as both Amy’s mentor and the person occupying her former institutional position. The dual role makes Dr. Ridley one of the most structurally interesting characters in the ensemble: someone positioned to help Amy rebuild while simultaneously representing what Amy lost. That’s not a role any actor could make land; it requires someone who can project authority without villainy, and Huffman has demonstrated that range across her career.

For viewers deciding whether to invest time in Doc, the casting is the strongest single argument in the show’s favor. The premise — memory loss, hospital drama, identity crisis — isn’t new to television. What the 2025 Fox series does differently is commit to the emotional specificity that makes those familiar elements work. Every cast addition, from Parker’s complex lead role to Murphy’s pastoral presence to Huffman’s commanding Season 2 arrival, serves the story rather than competing with it. The result is an ensemble that feels constructed rather than assembled, which is rarer than it should be in network drama. Three seasons in eighteen months is the network’s verdict: this cast is carrying the weight.